Yes. HPV vaccines have been carefully studied and monitored for many years with no serious safety concerns. Since the HPV vaccine was approved in 2006, more than 80 million doses have been administered. The most common side effect reported was pain and swelling at the shot location in the arm, fever, dizziness and nausea. These side effects are the same for most vaccines. Children with severe allergies to yeast or latex should not get certain HPV vaccines. Be sure to tell your doctor or nurse about any allergies.